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We are interested in the function of one, largely understudied, specialized glia cell in the CNS: the ependymal cell, to explore its role in multiple sclerosis and neurodegeneration. Ependymal cells are multi-ciliated cells that form the brain’s ventricular epithelium.

Although dysfunction in these cells has been linked to several pathologies, including ventricular enlargement, periventricular demyelination, and hydrocephalus, the exact role of these cell in most disease states are not known.

We assess material from people with neurodegenerative diseases, such as MS and Alzheimer's disease.