OUR RESEARCH
HUMAN MATERIAL
We are interested in the function of CSF border cells and glia biology, in particular exploring their roles in multiple sclerosis, Parkinson's disease, rare disease and neurodegenerative contexts.
Although dysfunction in these cells has been linked to several pathologies, the exact role of these cells in most disease states is not known.
We assess material from patients and donors, including brain tissue (from rapid autopsy programs), primary cells (from surgical material), PBMCs and iPSCs.
ANIMAL MODELLING
We use transgenic animal models to assess the impact of glia cell manipulation on brain health. We specialize in the use of conditional and inducible systems where we can target specific cell types for manipulation, and control the timing and extent of manipulation.
SINGLE CELL TECHNOLOGIES
We specialize in the use of single cell technologies including the preparation of cells from human and rodent tissues. We use high-throughput analysis approaches to dissect the intricate relationships between cells and cellular states to predict likely mechanisms of pathology or regeneration in disease or injury.
